Resetting the Master Body Clock: Treatment Innovations in Non-24-Hour Disorder

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Release Date: October 28, 2013
Expiration Date: October 28, 2014

Expected time to complete this activity as designed: 90 minutes
There are no fees for participating in or receiving credit for this online activity.

Program Overview

This accredited activity will focus on providing an increased awareness of Non-24-Hour Disorder, and consensus recommendations for diagnosis and treatment. Two leading experts in circadian rhythm disorders will review the data, symptomatology, and treatment of this disease occurrence in the totally blind population. Presenters will provide an overview of the master body clock, and the concept of a 24- versus a non-24-hour day as a foundation for understanding the epidemiology and clinical presentation of patients with Non-24-Hour Disorder. Current and emerging treatment will be discussed. Audience members will have the opportunity to hear from a patient currently being treated for this disorder and hear directly about her journey to find a diagnosis and treatment for the issues that were severely impacting her daily functioning.

Target Audience

This activity is designed for sleep specialists, primary care physicians, and nurses who have an interest in enhancing their clinical skills in the management of Non-24-Hour Disorder.

Learning Objectives

Upon completion of this educational activity, participants should be able to:

  • Describe the function of the master body clock and the concept of a 24- vs. non- 24-hour day
  • Outline the epidemiology and clinical presentation of patients suffering from Non-24-Hour Disorder
  • Incorporate consensus-based recommendations into clinical practice to accurately diagnose and treat patients suffering from Non-24-Hour Disorder
  • Summarize future directions in the understanding and utilization of emerging treatment options for patients with Non-24-Hour Disorder


The Patient’s Journey to Diagnosis and Treatment: A Patient Interview  – Helene A. Emsellem, MD
The Master Body Clock and a 24-versus a Non-24-Hour Day − Steven W. Lockley, PhD

Instructions for Participation and Credit

This activity is eligible for credit through October 28, 2014. After this date, this activity will expire and no further credit will be awarded.

  1. Read the target audience, learning objectives, and faculty disclosures.
  2. You may be asked to complete a short pre-test before accessing the educational content. This must be completed in order to move forward in the activity.
  3. Complete the educational content as designed.
  4. Complete the post-test. To receive a certificate, you must receive a passing score of 70%.
  5. Complete the activity evaluation survey to provide feedback and information useful for future programming.
  6. Certificates may be printed immediately after successfully completing the post-test and activity evaluation.

Faculty Biographies

Helene A. Emsellem, MD
Associate Clinical Professor of Neurology
George Washington University Medical Center
Washington, DC
Medical Director
The Center for Sleep and Wake Disorders
Chevy Chase, Maryland

Dr. Helene Emsellem received her medical degree from the George Washington University School of Medicine. She completed a rotating internship in psychiatry, internal medicine, and neurology, as well as a neurology residency and sub-specialty training in epileptology and clinical neurophysiology. Dr. Emsellem is an associate clinical professor of neurology at George Washington University Medical Center, and medical director at The Center for Sleep & Wake Disorders in Chevy Chase, Maryland, a full service sleep disorders center.

A firm believer in managing health through patient education, Dr. Emsellem is committed to the advancement of the field of sleep medicine. She has actively promoted sleep disorders awareness and the need for sleep education locally and nationally. She has also developed an outreach program on the importance of sleep in adolescence and the benefits of making changes in the middle and high school start times. As a physician and mother of three daughters, Dr. Emsellem understands on a personal and a scientific level how sleep deprivation adversely affects teen health, learning, mood, and performance – and how those negative effects impact family life. She helped establish the National Sleep Foundation’s Teen Sleep Awareness Program, and has been the keynote speaker on sleep issues. In addition to appearing as a sleep expert on radio and television shows, Dr. Emsellem has also authored many articles and book chapters, and her writings have appeared in many publication. Her book, Snooze…or Lose! focuses on improving teen's sleep habits.

Dr. Emsellem is committed to the advancement of the field of sleep medicine and is actively involved in clinical research in many areas of sleep medicine including excessive daytime sleepiness, narcolepsy, restless leg syndrome, obstructive sleep apnea, shift work sleep disorders, insomnia, and pediatric and adolescent sleep disorders.

Steven W. Lockley, PhD
Associate Professor of Medicine
Harvard Medical School
Neuroscientist, Division of Sleep Medicine,
Department of Medicine, Brigham and Women's Hospital
Boston, Massachusetts

Dr. Steven Lockley received his PhD in biological sciences from the University of Surrey, United Kingdom. He is an associate professor of medicine at Harvard Medical School and a neuroscientist in the Division of Sleep Medicine, Brigham and Women's Hospital, Boston. He is also an honorary associate professor at Warwick Medical School, UK, and adjunct associate professor at Monash University, Australia.

A main focus of Dr. Lockley’s research has been to understand circadian rhythm disorders in the blind and visually impaired. His translational approach includes use of a range of techniques including epidemiology, field-based physiological studies, and inpatient intensive physiological monitoring. His studies have led to the development of novel therapeutic strategies to treat non-24-hour sleep wake disorder, and Advanced- and Delayed Sleep Phase Syndrome. Dr. Lockley’s research has assessed the impact of extended work hours on health and safety, and he has developed interventions that reduce fatigue and medical errors in hospital residents. In addition, he has implemented large-scale occupational fatigue management and sleep disorders screening programs in several police forces nationwide. Dr. Lockley is a co-author of Sleep: A Very Short Introduction, and co-editor of Sleep, Health and Society and is on the editorial board for the journal Sleep.


MediCom Worldwide, Inc. CME CREDIT
Accreditation Statement: MediCom Worldwide, Inc. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Designation Statement: MediCom Worldwide, Inc. designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

MediCom Worldwide, Inc. NURSING CREDIT
Accreditation Statement: MediCom Worldwide, Inc., 101 Washington Street, Morrisville, PA 19067 is approved by the California Board of Registered Nursing, Provider Number CEP11380. MediCom designates this CNE activity for 1.5 contact hours. Program Number: 13-359-323


As an organization accredited by the Accreditation Council for Continuing Medical Education (ACCME), Accreditation Council for Pharmacy Education (ACPE) and California State Board of Registered Nursing, MediCom Worldwide, Inc. requires everyone who is a position to control the content of an educational activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines “relevant financial relationships” as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest. Accordingly, the following disclosures were made.

Faculty Disclosures

Dr. Helene Emsellem has received honoraria related to formal advisory activities from Vanda Pharmaceuticals, and Jazz Pharmaceuticals plc, as well as consultant fees from Jazz. She has received grant support related to research activities from Apnex Medical, Inc., ApniCure, Aerial BioPharma LLC, Comprehensive NeuoScience, Inc. (now Comprehensive Clinical Development), GlaxoSmithKline plc, Neurim Pharmaceuticals, Inc., Novo Nordisk A/S, UCB Biosciences Inc., and Vanda.

Dr. Steve Lockley has received honoraria as a consultant from American Family, Naturebright, Sound Oasis, Thomas Jefferson University, and Wyle Integrated Science and Engineering. He has received grant support related to research activities from Alcon Inc., Apollo Lighting, Biological Illuminations, Philips Lighting, Philips-Respironics Inc., ResMed Foundation, Swinburne University of Technology, and Vanda Pharmaceuticals Inc. In addition, Dr. Lockley has received unrestricted equipment gifts from Bionetics Corporation, Biological Illuminations, Philips Lighting, and ResMed Inc., as well as a fellowship gift from Optalert Pty. He has received royalties from Oxford University Press, and holds a patent which is assigned to the Brigham and Women’s Hospital.

Planning Committee Disclosures

The individuals listed below from MediCom Worldwide, Inc. reported the following for this activity: Joan Meyer, RN, MHA, executive director, has no relevant financial relationships.

Peer Reviewer Disclosure

In accordance with MediCom Worldwide, Inc. policy, all content is independently peer reviewed for balance, objectivity and commercial bias. The peer reviewers have no relevant financial relationships to disclose.

Off-Label Disclosures/Investigational Disclosures

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The opinions expressed in the educational activity are those of the faculty. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Further, attendees/participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program.

Dr. Emsellem and Dr. Lockley have indicated that they do not intend to discuss off-label uses of drugs, mechanical devices, biologics or diagnostics approved by the US Food and Drug Administration (FDA) for use in the US.

Dr. Emsellem and Dr. Lockley have indicated that they do intend to discuss investigational drugs, mechanical devices, biologics or diagnostics not approved by the FDA for use in the US.

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If you have any questions or concerns regarding this activity, please contact MediCom Worldwide, Inc. at 1-800-408-4242 or email us at

Provided by MediCom Worldwide, Inc.

This activity is supported by an educational grant from Vanda Pharmaceuticals.

©2013 MediCom Worldwide, Inc., 101 Washington St., Morrisville, PA 19067, 800-408-4242.
No portion of this material may be copied or duplicated without the expressed permission of MediCom Worldwide, Inc.

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